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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PNPLA4 hydrolyzes retinyl palmitate

atR-PALM + H2O → atROL + PALM(-) + H+

Reactome: R-HSA-8848355
Compartment: cytosol
Rhea: RHEA:13934

Inputs

atR-PALMCHEBI:17616, C36H60O2, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

atROLCHEBI:17336, C20H30O, cytosol
PALM(-)CHEBI:7896, C16H31O2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

retinyl-palmitate esterase activity of PNPLA4 [cytosol]EC 3.1.1.21; UniProt P41247

Literature

Molecular screening for GS2 lipase regulators: inhibition of keratinocyte retinylester hydrolysis by TIP47 J. Invest. Dermatol., 2006
A comparative study of human GS2, its paralogues, and its rat orthologue Biochem. Biophys. Res. Commun., 2007
GS2 as a retinol transacylase and as a catalytic dyad independent regulator of retinylester accretion Mol. Genet. Metab., 2009