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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG

2AG + acyl-CoA → DAG + CoA-SH

Reactome: R-HSA-6800334
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:32948

Inputs

2AGCHEBI:17389, C4H7O4R, cytosol
acyl-CoACHEBI:58342, C22H31N7O17P3SR, cytosol

Outputs

DAGCHEBI:17815, C5H6O5R2, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Catalysed by

2-acylglycerol O-acyltransferase activity of MOGAT1,2,3 [endoplasmic reticulum membrane]EC 2.3.1.22

Literature

Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption J. Biol. Chem., 2003
Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity Am. J. Physiol. Endocrinol. Metab., 2003
Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals Cytogenet. Genome Res., 2003
Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor Î³ in human hepatocytes and increases lipid accumulation Biochem. Biophys. Res. Commun., 2015