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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PNPLA4 hydrolyzes TAG

TAG + H2O → DAG + LCFA(-) + H+

Reactome: R-HSA-8848338
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:12045

Inputs

TAGCHEBI:17855, C6H5O6R3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

DAGCHEBI:17815, C5H6O5R2, cytosol
LCFA(-)CHEBI:57560, CO2R, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

triacylglycerol lipase activity of PNPLA4 [cytosol]EC 3.1.1.3; UniProt P41247

Literature

A comparative study of human GS2, its paralogues, and its rat orthologue Biochem. Biophys. Res. Commun., 2007
Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities J Biol Chem, 2004