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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Phosphorylated HSL dimer translocates from the cytosol to the lipid particle

phosphorylated HSL dimer → phosphorylated HSL dimer

Reactome: R-HSA-163554
Compartment: cytosol · lipid droplet
Rhea: None recorded

Inputs

phosphorylated HSL dimerR-HSA-163513, cytosol

Outputs

phosphorylated HSL dimerR-HSA-163435, lipid droplet

Literature

Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes J Biol Chem, 2003
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation J Cell Biol, 2003
Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes J Biol Chem, 2000
Molecular determinants for the association of human hormone-sensitive lipase with lipid droplets Nat Commun, 2025