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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]

DAG + FACoA → TAG + CoA-SH

Reactome: R-HSA-549192
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

DAGCHEBI:17815, C5H6O5R2, cytosol
FACoACHEBI:77636, C22H31N7O17P3SR, cytosol

Outputs

TAGCHEBI:17855, C6H5O6R3, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Catalysed by

diacylglycerol O-acyltransferase activity of DGAT2 [endoplasmic reticulum membrane]EC 2.3.1.20; UniProt Q96PD7

Literature

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members J Biol Chem, 2001
A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice Biochem Biophys Res Commun, 2003