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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Malate–aspartate shuttle

A coupled transport-and-reaction system that transfers cytosolic reducing equivalents into the mitochondrial matrix without moving NADH itself. 7 reactions, from Reactome R-HSA-9856872.

SLC25A12,13 exchange L-Glu and L-AspL-Asp + L-Glu + H+ → L-Asp + L-Glu + H+
SLC25A11 exchanges 2-OG and MALMAL + 2OG → MAL + 2OG
PXLP-K259-GOT1 transaminates 2-OG and L-AspL-Asp + 2OG → OA + L-Glu
GOT2 transaminates OA and L-GluOA + L-Glu → L-Asp + 2OG
MDH2 dimer dehydrogenates MALMAL + NAD+ → OA + NADH + H+
SLC25A18,22 import L-Glu, H+L-Glu + H+ → L-Glu + H+
MDH1 reduces OANADH + OA + H+ → MAL + NAD+