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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Ketone body metabolism

Hepatic formation and extrahepatic use of water-soluble acetyl-unit carriers. 11 reactions, from Reactome R-HSA-74182.

AACS ligates CoA-SH to ACA, forming ACA-CoAACA + ATP + CoA-SH → ACA-CoA + AMP + PPi
BDH2 dehydrogenates 3HBA3HBA + NAD+ → ACA + H+ + NADH
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACAbHMG-CoA → Ac-CoA + ACA
acetoacetic acid + NADH + H+ beta-hydroxybutyrate + NAD+ACA + NADH + H+ → bHBA + NAD+
2 acetyl-CoA acetoacetyl-CoA + CoA2 Ac-CoA → ACA-CoA + CoA-SH
acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASHACA-CoA + Ac-CoA → HMG CoA + CoA-SH
D-beta hydroxybutyrate+NAD+ acetoacetate+NADH+H+bHBA + NAD+ → ACA + NADH + H+
OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoAACA + SUCC-CoA → ACA-CoA + SUCCA
HMG CoA => acetoacetic acid + acetyl CoAHMG CoA → Ac-CoA + ACA
acetoacetyl-CoA + CoA 2 acetyl-CoAACA-CoA + CoA-SH → 2 Ac-CoA
ACSS3 ligates CoA to CH3COO-CH3COO- + ATP + CoA-SH → Ac-CoA + AMP + PPi