Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

acetoacetyl-CoA + CoA 2 acetyl-CoA

ACA-CoA + CoA-SH → 2 Ac-CoA

Reactome: R-HSA-74181
Compartment: mitochondrial matrix
Rhea: RHEA:21038

Inputs

ACA-CoACHEBI:57286, C25H36N7O18P3S, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Outputs

2 Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix

Catalysed by

acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]EC 2.3.1.9

Literature

3-Ketothiolase deficiency Eur J Pediatr, 1986