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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HMG CoA => acetoacetic acid + acetyl CoA

HMG CoA → Ac-CoA + ACA

Reactome: R-HSA-74180
Compartment: mitochondrial matrix
Rhea: RHEA:24405

Inputs

HMG CoACHEBI:15467, C27H44N7O20P3S, mitochondrial matrix

Outputs

Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix
ACACHEBI:15344, C4H6O3, mitochondrial matrix

Catalysed by

hydroxymethylglutaryl-CoA lyase activity of HMGCL dimer [mitochondrial matrix]EC 4.1.3.4

Literature

3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency. J Biol Chem, 1993