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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA

bHMG-CoA → Ac-CoA + ACA

Reactome: R-HSA-6788597
Compartment: cytosol
Rhea: RHEA:24405

Inputs

bHMG-CoACHEBI:43074, C27H39N7O20P3S, cytosol

Outputs

Ac-CoACHEBI:57288, C23H34N7O17P3S, cytosol
ACACHEBI:13705, C4H5O3, cytosol

Catalysed by

hydroxymethylglutaryl-CoA lyase activity of HMGCLL1:Mg2+ [cytosol]EC 4.1.3.4

Literature

Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase J. Biol. Chem., 2012
Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol J. Lipid Res., 2012