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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AACS ligates CoA-SH to ACA, forming ACA-CoA

ACA + ATP + CoA-SH → ACA-CoA + AMP + PPi

Reactome: R-HSA-5694494
Compartment: cytosol
Rhea: RHEA:16118

Inputs

ACACHEBI:13705, C4H5O3, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Outputs

ACA-CoACHEBI:57286, C25H36N7O18P3S, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

acetoacetate-CoA ligase activity of AACS [cytosol]EC 6.2.1.16; UniProt Q86V21

Literature

Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma Biochem. J., 2010
Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain Biochem. Pharmacol., 2003
Lipogenesis from ketone bodies in the isolated perfused rat liver. Evidence for the cytosolic activation of acetoacetate J. Biol. Chem., 1982
Ketone body metabolism and cardiovascular disease Am. J. Physiol. Heart Circ. Physiol., 2013