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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

acetoacetic acid + NADH + H+ beta-hydroxybutyrate + NAD+

ACA + NADH + H+ → bHBA + NAD+

Reactome: R-HSA-73912
Compartment: mitochondrial matrix
Rhea: RHEA:20523

Inputs

ACACHEBI:15344, C4H6O3, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Outputs

bHBACHEBI:17066, C4H8O3, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Catalysed by

3-hydroxybutyrate dehydrogenase activity of BDH1 tetramer [mitochondrial matrix]EC 1.1.1.30

Literature

Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart J Biol Chem, 1992