UniProt-reviewed human alpha-carbonic-anhydrase scope record. Dense upstream coverage is stratified by method, resolution band, assay, and fixed per-protein quotas so this paralog does not dominate the collection. This release links 25 source records to this accession, a selection rather than every record the upstream databases hold.
Normalized identity
- Gene
- CA2
- UniProt accession
P00918- Catalytic status
- Catalytic
- Review state
- UniProt-reviewed
- Taxon
- 9606
- Entry version
- 278, updated 2026-06-10
- Sequence identity
- v2, CRC64
2EC2BB7548F10558 - Sequence length
- 260 residues
- Selected structures
- 20
- Selected activities
- 4
- Reaction assignments
- 1
- ChEMBL targets
- CHEMBL205
Where the identity data came from
Each row is a UniProt snapshot used to build this release: when it was retrieved, its SHA-256 digest and the exact request. The snapshot files stay with the build and are not served here.
| Retrieved | Build-input snapshot | SHA-256 | Upstream request |
|---|---|---|---|
| 2026-07-14T09:21:31Z | raw/uniprot/entries/P00918.json | ed44906dd1b976f4c8b0399e9e3a7a4af09b673c035a201e218a4880821c1179 | Open exact source |
Source-reported location comments
- Cytoplasm
- Cell membrane
UniProt function text
Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption