Source assertion

PDBe/SIFTS maps PDB 12CA to UniProt P00918 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:12CA:UNIPROT:P00918
Subject dossier: ca2
Source chain: uniprot + pdbe
Upstream record: 12CA
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: In this release

Experimental structure

ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121

PDB ID: 12CA
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0x24b06afb0ec0) Å
SIFTS identifier: CAH2_HUMAN
Deposited: 19911001
Released / revised: 19921015 / 20240207

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	100.0%	100.0%	1–260

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A / A	Carbonic anhydrase 2polypeptide(L)	260 residues	not reported by the source	Genetically manipulated

Reading this structure

This is an experimentally determined structure, not a predicted model. A co-crystallised ligand, if any, does not by itself show binding affinity. The structure says nothing about kinetics, pathway rate or metabolic flux.

Snapshot provenance

Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:31Z	`raw/uniprot/entries/P00918.json`	`ed44906dd1b976f4c8b0399e9e3a7a4af09b673c035a201e218a4880821c1179`	Open exact source
2026-07-14T09:21:42Z	`raw/pdbe/mappings/12ca.json`	`b7cdbddedeff39118e21d08b006ec6c37a50bb77fc40d0ab60ddc2db1e0fbe92`	Open exact source
2026-07-14T09:22:12Z	`raw/pdbe/summary/chunk-01.json`	`dc1743d788d7927148f1208eac8f948637869ee61880999e81df1b79b57a0758`	Open exact source
2026-07-14T09:22:13Z	`raw/pdbe/experiment/chunk-01.json`	`fb047b9406db82cfc2256bd41ead50e4cd5ebf2ca5567e9be661676830294ed8`	Open exact source
2026-07-14T09:22:13Z	`raw/pdbe/molecules/chunk-01.json`	`4eb4d03de4d05f3f3a47f20fd76567c3ee5d6835db325358bbfe62bf45501b2a`	Open exact source