Source assertion
ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.
Lossless activity measurement
- Source-reported value
- = 8.72 uM
- Source-standardized value
- = 8720.0 nM
- Reported endpoint
- Ki
- Standardized endpoint
- Ki
- Reported upper bound
- not reported by the source
- Reported text value
- not reported by the source
- Standardization flag
- 1
- pChEMBL from source
- 5.06
Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.
Not comparable with other recordsCONDITION_MISSING
No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.
Assay and target
- ChEMBL activity
2259058- Target
CHEMBL205, SINGLE PROTEIN- Assay
CHEMBL1002074, Binding (B)- BAO format
BAO_0000357, single protein format- BAO endpoint
BAO_0000192- Target confidence
- 9, Direct single protein target assigned
- Source quality flags
- potential_duplicate=0; data_validity_comment=not reported by the source
Upstream assay description
Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot
Compound identity
- Molecule
CHEMBL421, SULFASALAZINE- Parent form
CHEMBL421; is_parent_form=true- Molecule type
- Small molecule
- Chirality source code
- 2
- Standard InChIKey
NCEXYHBECQHGNR-QZQOTICOSA-N- Canonical SMILES
O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O- Standard InChI
InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
Document
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
Bayram E, Senturk M, Kufrevioglu OI, Supuran CT.
- ChEMBL document
CHEMBL1152236- Journal / year
- Bioorg Med Chem, 2008
- PubMed
- 18819808
Comparison state
- Prequalified
- No — pairwise evaluation is still required
- Protein identity
- P00918, taxon 9606
- Variant / construct
- not reported by the source / not reported by the source
- Conditions
- pH not reported by the source; temperature not reported by the source °C; substrate not reported by the source; buffer not reported by the source
Snapshot provenance
Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.
| Retrieved | Snapshot | SHA-256 | Upstream request |
|---|---|---|---|
| 2026-07-14T09:21:31Z | raw/uniprot/entries/P00918.json | ed44906dd1b976f4c8b0399e9e3a7a4af09b673c035a201e218a4880821c1179 | Open exact source |
| 2026-07-14T09:22:21Z | raw/chembl/targets/CHEMBL205.json | a72211a98500a9ee255af420c327df455642440f828570896f227f637ac4d991 | Open exact source |
| 2026-07-14T09:22:24Z | raw/chembl/direct-assays/CHEMBL205.json | d77687649ad2c1120e6590de641bdef7dd078d9d00a04b12d1196c7031cceb65 | Open exact source |
| 2026-07-14T09:22:50Z | raw/chembl/assay-activities/CHEMBL1002074.json | fbaff35bf52d3d25c1fd568a37e6dc5219b7a179e087d114fd0de031c4ed6acc | Open exact source |
| 2026-07-14T09:23:18Z | raw/chembl/activities/2259058.json | c5f4d9d420436f08b65debfddbe1fd6e41eed8cfd0006b4418650d3e802b87b5 | Open exact source |
| 2026-07-14T09:23:18Z | raw/chembl/assays/CHEMBL1002074.json | b03f713838667948605bcad770bf6237238c8dffc5cedc4715423db981d86674 | Open exact source |
| 2026-07-14T09:23:16Z | raw/chembl/molecules/CHEMBL421.json | 1c3533138be7d06cb55fcdea1c59b78dd6cd8fdf33720bf5fd4f109380cba3e4 | Open exact source |
| 2026-07-14T09:23:15Z | raw/chembl/documents/CHEMBL1152236.json | fb726436f5f7c23d80784a02dc4a3b2bdd6e1e37f48047bb8a0155fbc4250001 | Open exact source |