About this dossier
UniProt-reviewed human alpha-carbonic-anhydrase scope record. Construct and assay context remain first-class comparison fields. This release links 11 source records to this accession, a selection rather than every record the upstream databases hold.
Normalized identity
- Gene
- CA12
- UniProt accession
O43570- Catalytic status
- Catalytic
- Review state
- UniProt-reviewed
- Taxon
- 9606
- Entry version
- 219, updated 2026-06-10
- Sequence identity
- v1, CRC64
9016216BF2CA6C0C - Sequence length
- 354 residues
- Selected structures
- 8
- Selected activities
- 2
- Reaction assignments
- 1
- ChEMBL targets
- CHEMBL3242
Where the identity data came from
Each row is a UniProt snapshot used to build this release: when it was retrieved, its SHA-256 digest and the exact request. The snapshot files stay with the build and are not served here.
| Retrieved | Build-input snapshot | SHA-256 | Upstream request |
|---|---|---|---|
| 2026-07-14T09:21:33Z | raw/uniprot/entries/O43570.json | 5e3bf6d20c857bc7f533ebfbfaf42d7ad6e84050aeb13c8f959567b94eb24d19 | Open exact source |
Source-reported location comments
- Membrane · Single-pass type I membrane protein
- Cell membrane
UniProt function text
Reversible hydration of carbon dioxide
Evidence records
Assay activityCA12 · ChEMBL activity 24568702456870, 1 comparison limitAssay activityCA12 · ChEMBL activity 26196362619636, 1 comparison limitExperimental structureCA12 · PDB 1JCZ1JCZExperimental structureCA12 · PDB 1JD01JD0Experimental structureCA12 · PDB 4HT24HT2Experimental structureCA12 · PDB 4KP54KP5Experimental structureCA12 · PDB 4KP84KP8Experimental structureCA12 · PDB 4Q0L4Q0LExperimental structureCA12 · PDB 6R716R71Experimental structureCA12 · PDB 6RPS6RPSReaction assignmentCA12 · RHEA:10748 assignmentRHEA:10748