Source assertion

PDBe/SIFTS maps PDB 4HT2 to UniProt O43570 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:4HT2:UNIPROT:O43570
Subject dossier: ca12
Source chain: uniprot + pdbe
Upstream record: 4HT2
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: In this release

Experimental structure

Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.

PDB ID: 4HT2
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0x218ff9432b70) Å
SIFTS identifier: CAH12_HUMAN
Deposited: 20121031
Released / revised: 20130410 / 20241127

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	100.0%	79.4%	30–291
1	`B`	`B`	100.0%	79.4%	30–291
1	`C`	`C`	100.0%	79.4%	30–291
1	`D`	`D`	100.0%	79.4%	30–291

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A, B, C, D / A, B, C, D	Carbonic anhydrase 12polypeptide(L)	263 residues	not reported by the source	Genetically manipulated

Reading this structure

This is an experimentally determined structure, not a predicted model. A co-crystallised ligand, if any, does not by itself show binding affinity. The structure says nothing about kinetics, pathway rate or metabolic flux.

Snapshot provenance

Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:33Z	`raw/uniprot/entries/O43570.json`	`5e3bf6d20c857bc7f533ebfbfaf42d7ad6e84050aeb13c8f959567b94eb24d19`	Open exact source
2026-07-14T09:22:06Z	`raw/pdbe/mappings/4ht2.json`	`73e822c2188b9393118935224c5d1d0c90c09159a1289e6aab9f3abe35e72292`	Open exact source
2026-07-14T09:22:14Z	`raw/pdbe/summary/chunk-02.json`	`79ac3fb4e9e30c8c858b4d8ed8bbe6f85e8e0d0e3630627a999691f40a3d330d`	Open exact source
2026-07-14T09:22:14Z	`raw/pdbe/experiment/chunk-02.json`	`e42f681713cd9cdce851cc48738b3c6e0f0c075d0006a640c484bcab84561898`	Open exact source
2026-07-14T09:22:15Z	`raw/pdbe/molecules/chunk-02.json`	`27833f4d4cb9a9bfcb110f6e551fe2a5ccef01ccea4dda947132af6c51bd66e6`	Open exact source