Source assertion

PDBe/SIFTS maps PDB 6RPS to UniProt O43570 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:6RPS:UNIPROT:O43570
Subject dossier: ca12
Source chain: uniprot + pdbe
Upstream record: 6RPS
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: In this release

Experimental structure

X-ray crystal structure of carbonic anhydrase XII complexed with a theranostic monoclonal antibody fragment

PDB ID: 6RPS
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0x24b06b06a1a0) Å
SIFTS identifier: CAH12_HUMAN
Deposited: 20190514
Released / revised: 20191113 / 20241016

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	94.0%	79.1%	31–291
1	`B`	`B`	94.0%	79.1%	31–291

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A, B / A, B	Carbonic anhydrase 12polypeptide(L)	283 residues	not reported by the source	Genetically manipulated

Reading this structure

This is an experimentally determined structure, not a predicted model. A co-crystallised ligand, if any, does not by itself show binding affinity. The structure says nothing about kinetics, pathway rate or metabolic flux.

Snapshot provenance

Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:33Z	`raw/uniprot/entries/O43570.json`	`5e3bf6d20c857bc7f533ebfbfaf42d7ad6e84050aeb13c8f959567b94eb24d19`	Open exact source
2026-07-14T09:22:05Z	`raw/pdbe/mappings/6rps.json`	`dbaac9814b3ee2435b40b6fc5991ed73aaebea1b1c06b0c846eeb50d994b7151`	Open exact source
2026-07-14T09:22:17Z	`raw/pdbe/summary/chunk-04.json`	`9993579d3f578cc0a0be921bfc6aa7a181fb8a074c2cd246c08a1da9b7d92dfc`	Open exact source
2026-07-14T09:22:18Z	`raw/pdbe/experiment/chunk-04.json`	`9fbf526866182ab693088d3c63735d5e62302d743c66532fd0163f0cb378a25b`	Open exact source
2026-07-14T09:22:19Z	`raw/pdbe/molecules/chunk-04.json`	`3e3b75bb7fa19acefd58e3b24f2d7e54feb541eeb253bea88d1e20ba0ccd936c`	Open exact source