Source assertion

PDBe/SIFTS maps PDB 4KP8 to UniProt O43570 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:4KP8:UNIPROT:O43570
Subject dossier: ca12
Source chain: uniprot + pdbe
Upstream record: 4KP8
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: In this release

Experimental structure

Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with 3-[(Pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide

PDB ID: 4KP8
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0x24b06affedb0) Å
SIFTS identifier: CAH12_HUMAN
Deposited: 20130513
Released / revised: 20131106 / 20241030

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	100.0%	79.4%	30–291
1	`B`	`B`	100.0%	79.4%	30–291
1	`C`	`C`	100.0%	79.4%	30–291
1	`D`	`D`	100.0%	79.4%	30–291

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A, B, C, D / A, B, C, D	Carbonic anhydrase 12polypeptide(L)	263 residues	not reported by the source	Genetically manipulated

Reading this structure

This is an experimentally determined structure, not a predicted model. A co-crystallised ligand, if any, does not by itself show binding affinity. The structure says nothing about kinetics, pathway rate or metabolic flux.

Snapshot provenance

Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:33Z	`raw/uniprot/entries/O43570.json`	`5e3bf6d20c857bc7f533ebfbfaf42d7ad6e84050aeb13c8f959567b94eb24d19`	Open exact source
2026-07-14T09:22:07Z	`raw/pdbe/mappings/4kp8.json`	`dfb2c8ef137e4c226538a54714e59d36ccbfe78da48b02cdb2d389777911a6bc`	Open exact source
2026-07-14T09:22:16Z	`raw/pdbe/summary/chunk-03.json`	`d318ed911ff2a8e3f25986a39c37baa2a3bb13c1d2a75d036924ca34ffa2b9cb`	Open exact source
2026-07-14T09:22:16Z	`raw/pdbe/experiment/chunk-03.json`	`8bbfae15de944b1cacdf21ee7a42caf9f09149a49b6fdf48f69df854b06973c9`	Open exact source
2026-07-14T09:22:17Z	`raw/pdbe/molecules/chunk-03.json`	`e94951408bdc68a6d0767211c754ae03dc74c4cf253ad3a7626c02d4aaba5eeb`	Open exact source