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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Proline catabolism

Source-linked human proline catabolism. 5 reactions, from Reactome R-HSA-70688.

1PYR-5COOH spontaneously hydrolyses to L-GluSS1PYR-5COOH + H2O → L-Glu5S
PRODH oxidises L-Pro to 1PYR-5COOHL-Pro + FAD → 1PYR-5COOH + FADH2 + 2 H+
ALDH4A1 oxidises L-GluSS to GluL-Glu5S + NAD+ + H2O → L-Glu + NADH + 2 H+
PRODH2 oxidises HPRO to 1PYR-3OH-5COOHHPRO + FAD → FADH2 + H2O + 1PYR-3OH-5COOH
ALDH4A1 oxidizes 1PYR-3OH-5COOH1PYR-3OH-5COOH + 2 H2O + NAD+ → 4OH-L-Glu + H+ + NADH