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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PRODH oxidises L-Pro to 1PYR-5COOH

L-Pro + FAD → 1PYR-5COOH + FADH2 + 2 H+

Reactome: R-HSA-70670
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: RHEA:23785

Inputs

L-ProCHEBI:60039, C5H9NO2, mitochondrial matrix
FADCHEBI:57692, C27H30N9O15P2, mitochondrial inner membrane

Outputs

1PYR-5COOHCHEBI:17388, C5H6NO2, mitochondrial matrix
FADH2CHEBI:58307, C27H33N9O15P2, mitochondrial inner membrane
2 H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor of PRODH [mitochondrial inner membrane]EC 1.5.5; UniProt O43272

Literature

Functional consequences of PRODH missense mutations Am J Hum Genet, 2005