Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALDH4A1 oxidises L-GluSS to Glu

L-Glu5S + NAD+ + H2O → L-Glu + NADH + 2 H+

Reactome: R-HSA-70679
Compartment: mitochondrial matrix
Rhea: RHEA:30236

Inputs

L-Glu5SCHEBI:58066, C5H9NO3, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
2 H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

L-glutamate gamma-semialdehyde dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix]EC 1.2.1.88

ALDH4A1 oxidises L-GluSS to Glu

Inputs

Outputs

Catalysed by

Literature