Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALDH4A1 oxidizes 1PYR-3OH-5COOH

1PYR-3OH-5COOH + 2 H2O + NAD+ → 4OH-L-Glu + H+ + NADH

Reactome: R-HSA-9929439
Compartment: mitochondrial matrix
Rhea: RHEA:31156

Inputs

1PYR-3OH-5COOHCHEBI:62612, C5H6NO3, mitochondrial matrix
2 H2OCHEBI:15377, H2O, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Outputs

4OH-L-GluCHEBI:6331, C5H8NO5, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix

Catalysed by

L-glutamate gamma-semialdehyde dehydrogenase activity of ALDH4A1 dimer [mitochondrial matrix]EC 1.2.1.88

ALDH4A1 oxidizes 1PYR-3OH-5COOH

Inputs

Outputs

Catalysed by

Literature