Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PRODH2 oxidises HPRO to 1PYR-3OH-5COOH

HPRO + FAD → FADH2 + H2O + 1PYR-3OH-5COOH

Reactome: R-HSA-8955817
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: RHEA:52513

Inputs

HPROCHEBI:58375, C5H9NO3, mitochondrial matrix
FADCHEBI:57692, C27H30N9O15P2, mitochondrial inner membrane

Outputs

FADH2CHEBI:58307, C27H33N9O15P2, mitochondrial inner membrane
H2OCHEBI:15377, H2O, mitochondrial matrix
1PYR-3OH-5COOHCHEBI:62612, C5H6NO3, mitochondrial matrix

Catalysed by

proline dehydrogenase activity of PRODH2 [mitochondrial inner membrane]EC 1.5.5.2; UniProt Q9UF12

Literature

Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria Biochem. J., 2015