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Pentose phosphate pathway
Oxidative and non-oxidative reactions that connect glucose 6-phosphate to NADPH production and ribose-phosphate pools. 20 reactions, from Reactome R-HSA-71336.
- PRPS1 dimer pyrophosphorylates R5P using dATPR5P + dATP → PRPP + dAMP + H+
- D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate xylulose 5-phosphate+ribose 5-phosphateGA3P + SH7P → R5P + XY5P
- D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate xylulose 5-phosphate + D-erythrose 4-phosphateGA3P + Fru(6)P → XY5P + E4P
- D-fructose 6-phosphate + D-erythrose 4-phosphate sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphateFru(6)P + E4P → SH7P + GA3P
- RPIA isomerizes ribose 5-phosphate to D-ribulose 5-phosphateR5P → RU5P
- RPE dimers isomerize XY5P to RU5PXY5P → RU5P
- DERA cleaves dR5P to GA3P and CH3CHOdR5P → GA3P + CH3CHO
- PGM2:Mg2+ isomerises R1P to R5PR1P → R5P
- G6PD multimers dehydrogenate G6PG6P + NADP+ → D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
- PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphateD-Glucono-1,5-lactone 6-phosphate + H2O → PDG + H+
- PGD decarboxylates 6-phospho-D-gluconatePDG + NADP+ → RU5P + CO2 + NADPH
- RPE dimers isomerise RU5P to XY5PRU5P → XY5P
- RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphateRU5P → R5P
- ribose 5-phosphate + xylulose 5-phosphate sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphateXY5P + R5P → GA3P + SH7P
- sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate D-erythrose 4-phosphate + D-fructose 6-phosphateSH7P + GA3P → Fru(6)P + E4P
- xylulose 5-phosphate + D-erythrose 4-phosphate D-glyceraldehyde 3-phosphate + D-fructose 6-phosphateXY5P + E4P → GA3P + Fru(6)P
- PRPS dimers pyrophosphorylate R5P using ATPR5P + ATP → PRPP + AMP + H+
- RBKS phosphorylates ribose to R5PD-ribose + ATP → R5P + ADP + H+
- SHPK phosphorylates Sedo to Sedo7PSedo + ATP → SH7P + ADP + H+
- PGM2:Mg2+ isomerises dR1P to dR5PdR1P → dR5P