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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PRPS dimers pyrophosphorylate R5P using ATP

R5P + ATP → PRPP + AMP + H+

Reactome: R-HSA-73580
Compartment: cytosol
Rhea: RHEA:15610

Inputs

R5PCHEBI:78346, C5H9O8P, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

PRPPCHEBI:58017, C5H8O14P3, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

ribose phosphate diphosphokinase activity of PRPS dimers [cytosol]EC 2.7.6.1

Literature

Human phosphoribosylpyrophosphate synthetase J Biol Chem, 1971
Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance Microbiol Mol Biol Rev, 2017