SHPK phosphorylates Sedo to Sedo7P
Sedo + ATP → SH7P + ADP + H+
- Reactome
- R-HSA-8959719
- Compartment
- cytosol
- Rhea
- RHEA:23845
Inputs
- SedoCHEBI:16802, C7H14O7, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
Outputs
- SH7PCHEBI:57483, C7H13O10P, cytosol
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- sedoheptulokinase activity of SHPK [cytosol]EC 2.7.1.14; UniProt Q9UHJ6
Literature
- The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism Cell Metab., 2012
- Sedoheptulokinase deficiency due to a 57-kb deletion in cystinosis patients causes urinary accumulation of sedoheptulose: elucidation of the CARKL gene Hum. Mutat., 2008
- Characterization of mammalian sedoheptulokinase and mechanism of formation of erythritol in sedoheptulokinase deficiency FEBS Lett., 2008