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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PGD decarboxylates 6-phospho-D-gluconate

PDG + NADP+ → RU5P + CO2 + NADPH

Reactome: R-HSA-71299
Compartment: cytosol
Rhea: RHEA:10117

Inputs

PDGCHEBI:58759, C6H10O10P, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

RU5PCHEBI:58121, C5H9O8P, cytosol
CO2CHEBI:16526, CO2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Catalysed by

phosphogluconate dehydrogenase (decarboxylating) activity of PGD dimer [cytosol]EC 1.1.1.44

Literature

Limiting role of 6-phosphogluconolactonase in erythrocyte hexose monophosphate pathway metabolism J Lab Clin Med, 1985
Half-site reactivity in 6-phosphogluconate dehydrogenase from human erythrocytes Biochem J, 1985
6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species Biochim Biophys Acta, 1998