G6PD multimers dehydrogenate G6P
G6P + NADP+ → D-Glucono-1,5-lactone 6-phosphate + NADPH + H+
- Reactome
- R-HSA-70377
- Compartment
- cytosol
- Rhea
- RHEA:15842
Inputs
- G6PCHEBI:58225, C6H11O9P, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Outputs
- D-Glucono-1,5-lactone 6-phosphateCHEBI:57955, C6H9O9P, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- glucose-6-phosphate dehydrogenase activity of G6PD dimer and tetramer [cytosol]EC 1.1.1.49
Literature
- Enzymic properties of different types of human erythrocyte glucose-6-phosphate dehydrogenase, with characterization of two new genetic variants J Clin Invest, 1968
- Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency Structure, 2000
- Glucose-6-phosphate dehydrogenase: a biomarker and potential therapeutic target for cancer Anticancer Agents Med Chem, 2014