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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate D-erythrose 4-phosphate + D-fructose 6-phosphate

SH7P + GA3P → Fru(6)P + E4P

Reactome: R-HSA-71334
Compartment: cytosol
Rhea: RHEA:17054

Inputs

SH7PCHEBI:57483, C7H13O10P, cytosol
GA3PCHEBI:59776, C3H5O6P, cytosol

Outputs

Fru(6)PCHEBI:57634, C6H11O9P, cytosol
E4PCHEBI:16897, C4H7O7P, cytosol

Catalysed by

transaldolase activity of TALDO1 dimer [cytosol]EC 2.2.1.2

Literature

Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence J Biol Chem, 1994
The three-dimensional structure of human transaldolase FEBS Lett., 2000
Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway. Am J Hum Genet, 2001