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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Glutathione metabolism

Synthesis, oxidation, reduction and conjugation of the glutathione redox buffer. 9 reactions, from Reactome R-HSA-174403.

CNDP2:2Mn2+ dimer hydrolyses CysGlyCysGly + H2O → L-Cys + Gly
GSH translocates from cytosol to extracellular regionGSH → GSH
GGCT transforms gGluCys to OPROgGluCys → L-Cys + OPRO
OPLAH hydrolyses OPRO to L-GluATP + 2 H2O + OPRO → ADP + L-Glu + Pi
CysGly translocates from extracellular region to cytosolCysGly → CysGly
GCL ligates L-Glu to L-CysL-Glu + L-Cys + ATP → gGluCys + ADP + Pi
GSS:Mg2+ dimer synthesizes GSHgGluCys + Gly + ATP → GSH + ADP + Pi
CHAC1,2 cleaves GSH to OPRO and CysGlyGSH → OPRO + CysGly
GGT dimers hydrolyse GSHGSH + H2O → CysGly + L-Glu