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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Fructose metabolism

Tissue-contextual routes that phosphorylate and split fructose before its carbon joins central carbohydrate metabolism. 7 reactions, from Reactome R-HSA-5652084.

AKR1B1 reduces Glc to D-sorbitolGlc + NADPH + H+ → D-sorbitol + NADP+
SORD oxidizes D-sorbitol to FruD-sorbitol + NAD+ → NADH + H+ + keto-D-Fru
GLYCTK phosphorylates DGA to 3PDGADGA + ATP → 3PDGA + ADP + H+
ALDH1A1 oxidises GA to DGAGA + NAD+ + H2O → DGA + NADH + 2 H+
KHK dimer phosphorylates Fru to Fru 1-PATP + beta-D-Fru → ADP + beta-D-Fru 1-P + H+
ALDOB tetramer cleaves Fru-1-P to GA and DHAPbeta-D-Fru 1-P → GA + DHAP
DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphateATP + GA → ADP + GA3P