KHK dimer phosphorylates Fru to Fru 1-P
ATP + beta-D-Fru → ADP + beta-D-Fru 1-P + H+
- Reactome
- R-HSA-70333
- Compartment
- cytosol
- Rhea
- RHEA:18146
Inputs
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- beta-D-FruCHEBI:28645, C6H12O6, cytosol
Outputs
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- beta-D-Fru 1-PCHEBI:138881, C6H11O9P, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- ketohexokinase activity of KHK dimer [cytosol]EC 2.7.1.3
Literature
- Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria Diabetes, 2003
- Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase) Hum Mol Genet, 1994
- Both isoforms of ketohexokinase are dispensable for normal growth and development Physiol. Genomics, 2010
- Genes required for fructose metabolism are expressed in Purkinje cells in the cerebellum Brain Res. Mol. Brain Res., 2005
- Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice Proc. Natl. Acad. Sci. U.S.A., 2012
- Structures of alternatively spliced isoforms of human ketohexokinase Acta Crystallogr D Biol Crystallogr, 2009