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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALDOB tetramer cleaves Fru-1-P to GA and DHAP

beta-D-Fru 1-P → GA + DHAP

Reactome: R-HSA-70342
Compartment: cytosol
Rhea: RHEA:30852

Inputs

beta-D-Fru 1-PCHEBI:138881, C6H11O9P, cytosol

Outputs

GACHEBI:17378, C3H6O3, cytosol
DHAPCHEBI:57642, C3H5O6P, cytosol

Catalysed by

fructose-1-phosphate aldolase activity of ALDOB tetramer [cytosol]

Literature

Hereditary fructose intolerance J. Med. Genet., 1998
The structure of human liver fructose-1,6-bisphosphate aldolase Acta Crystallogr D Biol Crystallogr, 2001
[The metabolism of fructose-1-phosphate in the liver.] Biochim Biophys Acta, 1953
Distribution of fructose diphosphate aldolase variants in biological systems Biochemistry, 1969
Isolation of fructose diphosphate aldolases A, B, and C Biochemistry, 1969
Kinetic and immunological abnormalities of aldolase B in hereditary fructose intolerance Biochem. Soc. Trans., 1975