Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GLYCTK phosphorylates DGA to 3PDGA

DGA + ATP → 3PDGA + ADP + H+

Reactome: R-HSA-6799495
Compartment: cytosol
Rhea: RHEA:23517

Inputs

DGACHEBI:16659, C3H5O4, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

3PDGACHEBI:58272, C3H4O7P, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

glycerate kinase activity of GLYCTK [cytosol]EC 2.7.1.31; UniProt Q8IVS8

Literature

Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2 DNA Seq., 2006
D-glycerate kinase deficiency as a cause of D-glyceric aciduria FEBS Lett., 1989
D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK) Hum. Mutat., 2010