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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SORD oxidizes D-sorbitol to Fru

D-sorbitol + NAD+ → NADH + H+ + keto-D-Fru

Reactome: R-HSA-5652195
Compartment: cytosol
Rhea: RHEA:33033

Inputs

D-sorbitolCHEBI:17924, C6H14O6, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

NADHCHEBI:57945, C21H27N7O14P2, cytosol
H+CHEBI:15378, H, cytosol
keto-D-FruCHEBI:48095, C6H12O6, cytosol

Catalysed by

L-iditol 2-dehydrogenase (NAD+) activity of SORD tetramer [cytosol]EC 1.1.1.14

Literature

[The mechanism of the formation of seminal fructose and fetal fructose] Biochim. Biophys. Acta, 1960
Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme Eur. J. Biochem., 1989
Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase Biochem. J., 1983
X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase Structure, 2003