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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate

ATP + GA → ADP + GA3P

Reactome: R-HSA-70349
Compartment: cytosol
Rhea: RHEA:13942

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
GACHEBI:17378, C3H6O3, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
GA3PCHEBI:59776, C3H5O6P, cytosol

Catalysed by

triokinase activity of TKFC:2Mg2+ dimer [cytosol]EC 2.7.1.28

Literature

Dihydroxyacetone metabolism by human erythrocytes: demonstration of triokinase activity and its characterization Blood, 1973
Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases Biochem. Biophys. Res. Commun., 2005
[The metabolism of fructose-1-phosphate in the liver.] Biochim Biophys Acta, 1953
Liver protein profiling in chronic hepatitis C: identification of potential predictive markers for interferon therapy outcome J. Proteome Res., 2012
Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements J. Biol. Chem., 2014
Serum dihydroxyacetone kinase peptide m/z 520.3 as predictor of disease severity in patients with compensated chronic hepatitis B J Transl Med, 2013