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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Galactose catabolism

The Leloir-route chemistry that converts galactose-derived carbon into glucose-phosphate intermediates. 6 reactions, from Reactome R-HSA-70370.

GALK1 phosphorylates Gal to Gal1PATP + alpha-D-Gal → ADP + Gal1P + H+
GALT transfers UMP from UDP-Glc to Gal1P to form UDP-GalUDP-Glc + Gal1P → G1P + UDP-Gal
GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-GlcUDP-Gal → UDP-Glc
PGM1:Mg2+ isomerises G1P to G6PG1P → G6P
AKR1B1 reduces galactose to galactitolalpha-D-Gal + H+ + NADPH → galactitol + NADP+
GALM converts beta-D-GAL to alpha-D-GALbeta-D-Gal → alpha-D-Gal