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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GALK1 phosphorylates Gal to Gal1P

ATP + alpha-D-Gal → ADP + Gal1P + H+

Reactome: R-HSA-70355
Compartment: cytosol
Rhea: RHEA:13554, RHEA:13553

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
alpha-D-GalCHEBI:28061, C6H12O6, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
Gal1PCHEBI:17973, C6H13O9P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

galactokinase activity of GALK1 [cytosol]EC 2.7.1.6; UniProt P51570

Literature

Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2 Biochem Biophys Res Commun, 1995