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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal

UDP-Glc + Gal1P → G1P + UDP-Gal

Reactome: R-HSA-70361
Compartment: cytosol
Rhea: RHEA:13990

Inputs

UDP-GlcCHEBI:58885, C15H22N2O17P2, cytosol
Gal1PCHEBI:17973, C6H13O9P, cytosol

Outputs

G1PCHEBI:58601, C6H11O9P, cytosol
UDP-GalCHEBI:66914, C15H22N2O17P2, cytosol

Catalysed by

UDP-glucose:hexose-1-phosphate uridylyltransferase activity of GALT [cytosol]EC 2.7.7.12; UniProt P07902

Literature

Molecular characterization of two galactosemia mutations: correlation of mutations with highly conserved domains in galactose-1-phosphate uridyl transferase Am J Hum Genet, 1991
Molecular basis of galactosemia: mutations and polymorphisms in the gene encoding human galactose-1-phosphate uridylyltransferase Proc. Natl. Acad. Sci. U.S.A., 1991