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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AKR1B1 reduces galactose to galactitol

alpha-D-Gal + H+ + NADPH → galactitol + NADP+

Reactome: R-HSA-9931850
Compartment: cytosol
Rhea: RHEA:37969, RHEA:12791

Inputs

alpha-D-GalCHEBI:28061, C6H12O6, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Outputs

galactitolCHEBI:16813, C6H14O6, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

aldose reductase (NADPH) activity of AKR1B1 [cytosol]EC 1.1.1.21; UniProt P15121

Literature

Presence of a closely related subgroup in the aldo-ketoreductase family of the mouse Eur J Biochem, 1995
Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease Adv Exp Med Biol, 2018
The accumulation of dulcitol and water in rabbit lens incubated with galactose Biochim Biophys Acta, 1962
Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor Science, 1973
Polyol accumulation in cultured human lens epithelial cells Exp Eye Res, 1991
The in vitro effects of galactose and its derivatives on rat brain Mg2+-ATPase activity Pharmacol Toxicol, 2002