COFACTORS

Vitamins & cofactors

Uptake, activation, transport and assembly of vitamin-derived and inorganic cofactors used throughout the network.

COFACTORS4 pathway backbones

Folate & pterines31 represented events · source Water-soluble vitamins146 represented events · source Cofactor metabolism34 represented events · source Mitochondrial Fe–S assembly6 represented events · source

These routes occupy a stable territory in the publication map and link to their source records for closer inspection.

Vitamins become metabolically useful only after transport and chemical activation. The resulting cofactors participate in reaction classes—acyl transfer, redox, carboxylation, rearrangement or one-carbon transfer—rather than acting as generic energy ingredients.

A cofactor lens exposes repeated chemistry across distant pathways. It also helps distinguish a nutrient precursor from the active molecular form that appears in an enzyme reaction.

Ideas to carry into the map

The active cofactor is not always the dietary molecule.
Cofactors reveal recurring reaction chemistry.
Transport and compartmental activation matter.

Pathways in this field note

Folate & pterinesR-HSA-196757 · 31 represented events

Folate transport and interconversion of tetrahydrofolate-bound one-carbon units.

On the map Reactome source

Water-soluble vitaminsR-HSA-196849 · 146 represented events

Metabolism and transport of the B-vitamin and vitamin-C families.

On the map Reactome source

Cofactor metabolismR-HSA-8978934 · 34 represented events

Assembly and handling of non-vitamin and vitamin-derived cofactor systems.

On the map Reactome source

Mitochondrial Fe–S assemblyR-HSA-1362409 · 6 represented events

Stepwise construction and transfer of iron–sulfur clusters to mitochondrial recipient proteins.

On the map Reactome source

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