About this dossier

UniProt-reviewed human alpha-carbonic-anhydrase scope record. Evidence cards are admitted only after source identity, construct, measurement and provenance checks. This release links 13 source records to this accession, a selection rather than every record the upstream databases hold.

Normalized identity

Gene: CA1
UniProt accession: P00915
Catalytic status: Catalytic
Review state: UniProt-reviewed
Taxon: 9606
Entry version: 235, updated 2026-06-10
Sequence identity: v2, CRC64 4959E5FA25E374F8
Sequence length: 261 residues
Selected structures: 10
Selected activities: 2
Reaction assignments: 1
ChEMBL targets: CHEMBL261

Where the identity data came from

Each row is a UniProt snapshot used to build this release: when it was retrieved, its SHA-256 digest and the exact request. The snapshot files stay with the build and are not served here.

Retrieved	Build-input snapshot	SHA-256	Upstream request
2026-07-14T09:21:31Z	`raw/uniprot/entries/P00915.json`	`b3bde31c781c25e15bf68bd00c694f9b1027cdc49ec26688ca7d047de2a6ca95`	Open exact source

Source-reported location comments

Cytoplasm

UniProt function text

Catalyzes the reversible hydration of carbon dioxide (PubMed:10550681, PubMed:16506782, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17407288, PubMed:18618712, PubMed:19186056, PubMed:19206230). Can hydrate cyanamide to urea (PubMed:10550681)

Evidence records