Source assertion

PDBe/SIFTS maps PDB 5E2M to UniProt P00915 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:5E2M:UNIPROT:P00915
Subject dossier: ca1
Source chain: uniprot + pdbe
Upstream record: 5E2M
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: In this release

Experimental structure

Crystal structure of human carbonic anhydrase isozyme I with 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide

PDB ID: 5E2M
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0x24b06afff290) Å
SIFTS identifier: CAH1_HUMAN
Deposited: 20151001
Released / revised: 20161005 / 20240110

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	100.0%	99.2%	3–261
1	`B`	`B`	100.0%	99.2%	3–261

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A, B / A, B	Carbonic anhydrase 1polypeptide(L)	260 residues	not reported by the source	Genetically manipulated

Reading this structure

This is an experimentally determined structure, not a predicted model. A co-crystallised ligand, if any, does not by itself show binding affinity. The structure says nothing about kinetics, pathway rate or metabolic flux.

Snapshot provenance

Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:31Z	`raw/uniprot/entries/P00915.json`	`b3bde31c781c25e15bf68bd00c694f9b1027cdc49ec26688ca7d047de2a6ca95`	Open exact source
2026-07-14T09:21:35Z	`raw/pdbe/mappings/5e2m.json`	`7fe0789c8f51eefef6637c57b60a2ed7e0fcd3c60e36aa29302d08d587df3a4f`	Open exact source
2026-07-14T09:22:16Z	`raw/pdbe/summary/chunk-03.json`	`d318ed911ff2a8e3f25986a39c37baa2a3bb13c1d2a75d036924ca34ffa2b9cb`	Open exact source
2026-07-14T09:22:16Z	`raw/pdbe/experiment/chunk-03.json`	`8bbfae15de944b1cacdf21ee7a42caf9f09149a49b6fdf48f69df854b06973c9`	Open exact source
2026-07-14T09:22:17Z	`raw/pdbe/molecules/chunk-03.json`	`e94951408bdc68a6d0767211c754ae03dc74c4cf253ad3a7626c02d4aaba5eeb`	Open exact source