Source assertion

PDBe/SIFTS maps PDB 2HFW to UniProt P07451 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:2HFW:UNIPROT:P07451
Subject dossier: ca3
Source chain: uniprot + pdbe
Upstream record: 2HFW
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: In this release

Experimental structure

Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III

PDB ID: 2HFW
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0x2eca05fa9e40) Å
SIFTS identifier: CAH3_HUMAN
Deposited: 20060626
Released / revised: 20070508 / 20240214

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	98.0%	100.0%	1–260

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A / A	Carbonic anhydrase 3polypeptide(L)	260 residues	K64H, R67N, C182S, C187S	Genetically manipulated

Reading this structure

This is an experimentally determined structure, not a predicted model. A co-crystallised ligand, if any, does not by itself show binding affinity. The structure says nothing about kinetics, pathway rate or metabolic flux.

Snapshot provenance

Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:32Z	`raw/uniprot/entries/P07451.json`	`cf4d0cf96a6252efc608b8ee5c8b35b502dffa8996e6dbb74c6fa4b67ce3394f`	Open exact source
2026-07-14T09:21:49Z	`raw/pdbe/mappings/2hfw.json`	`e1db3c5e6386fe4ccec4387812dc828f4e05304f9928b5e329a34e391c83aa89`	Open exact source
2026-07-14T09:22:12Z	`raw/pdbe/summary/chunk-01.json`	`dc1743d788d7927148f1208eac8f948637869ee61880999e81df1b79b57a0758`	Open exact source
2026-07-14T09:22:13Z	`raw/pdbe/experiment/chunk-01.json`	`fb047b9406db82cfc2256bd41ead50e4cd5ebf2ca5567e9be661676830294ed8`	Open exact source
2026-07-14T09:22:13Z	`raw/pdbe/molecules/chunk-01.json`	`4eb4d03de4d05f3f3a47f20fd76567c3ee5d6835db325358bbfe62bf45501b2a`	Open exact source