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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Unknown enzyme hydrogenates HPP

H+ + HPP + NADH → NAD+ + p-hydroxyphenyllactate

Reactome: R-HSA-9971565
Compartment: cytosol
Rhea: RHEA:34557

Inputs

H+CHEBI:15378, H, cytosol
HPPCHEBI:36242, C9H7O4, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol

Outputs

NAD+CHEBI:57540, C21H26N7O14P2, cytosol
p-hydroxyphenyllactateCHEBI:10980, C9H9O4, cytosol

Catalysed by

L-2-hydroxycarboxylate dehydrogenase (NAD+) activity of Unknown enzyme [cytosol]EC 1.1.1.337

Literature

Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease JCI Insight, 2020
The reduction of aromatic alpha-keto acids by cytoplasmic malate dehydrogenase and lactate dehydrogenase Biochem Genet, 1987
Tyrosinemia: a review Pediatr Dev Pathol, 2001