MSMO1 oxidizes 4a-me-5a-cholest-8-en-3b-ol to 4a-carboxy-5a-cholest-8-ene-3b-ol
4a-me-5a-cholest-8-en-3b-ol + 6 CYP450:Fe2+ + 5 H+ + 3 O2 → 4a-carboxy-5a-cholest-8-en-3b-ol + 6 CYP450:Fe3+ + 4 H2O
- Reactome
- R-HSA-9947207
- Compartment
- endoplasmic reticulum membrane · cytosol
- Rhea
- RHEA:62781
Inputs
- 4a-me-5a-cholest-8-en-3b-olCHEBI:87051, C28H48O, endoplasmic reticulum membrane
- 6 CYP450:Fe2+R-HSA-8957354, endoplasmic reticulum membrane
- 5 H+CHEBI:15378, H, cytosol
- 3 O2CHEBI:15379, O2, cytosol
Outputs
- 4a-carboxy-5a-cholest-8-en-3b-olCHEBI:87055, C28H45O3, endoplasmic reticulum membrane
- 6 CYP450:Fe3+R-HSA-8957351, endoplasmic reticulum membrane
- 4 H2OCHEBI:15377, H2O, cytosol
Catalysed by
- C-4 methylsterol oxidase activity of MSMO1 [endoplasmic reticulum membrane]EC 1.14.18.9; UniProt Q15800