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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol

4,4-diMe-5-cholest-8-en-3-ol + 6 CYP450:Fe2+ + 5 H+ + 3 O2 → 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol + 6 CYP450:Fe3+ + 4 H2O

Reactome
R-HSA-9947203
Compartment
endoplasmic reticulum membrane · cytosol
Rhea
RHEA:62777

Inputs

Outputs

  • 4a-carboxy-4b-me-5a-cholest-8-en-3b-olCHEBI:87047, C29H47O3, endoplasmic reticulum membrane
  • 6 CYP450:Fe3+R-HSA-8957351, endoplasmic reticulum membrane
  • 4 H2OCHEBI:15377, H2O, cytosol

Catalysed by

Literature

  1. Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay J Clin Invest, 2011