Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol

4,4-diMe-8,14-cholestadien-3b-ol + H+ + NADPH → 4,4-diMe-5-cholest-8-en-3-ol + NADP+

Reactome: R-HSA-9946140
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:46812, RHEA:46813

Inputs

4,4-diMe-8,14-cholestadien-3b-olCHEBI:78904, C29H48O, endoplasmic reticulum membrane
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Outputs

4,4-diMe-5-cholest-8-en-3-olCHEBI:87044, C29H50O, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

Delta14-sterol reductase activity of TM7SF2 [endoplasmic reticulum membrane]EC 1.3.1.70; UniProt O76062

Literature

Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis Biochim Biophys Acta, 2006