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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one

4a-carboxy-5a-cholest-8-en-3b-ol + NADP+ → 5a-cholest-8-en-3-one + CO2 + NADPH

Reactome: R-HSA-9945787
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:46848, RHEA:46849

Inputs

4a-carboxy-5a-cholest-8-en-3b-olCHEBI:87055, C28H45O3, endoplasmic reticulum membrane
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

5a-cholest-8-en-3-oneCHEBI:87056, C27H44O, endoplasmic reticulum membrane
CO2CHEBI:16526, CO2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Catalysed by

3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity of NSDHL [endoplasmic reticulum membrane]EC 1.1.1.170; UniProt Q15738

Literature

The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase Nat Genet, 1999